Anti-Adiponectin Antibody [D02-7B10] (Biotin) (A280196)

Anti-Adiponectin Antibody [D02-7B10] (Biotin)

Mouse monoclonal [D02-7B10] antibody to Adiponectin (Biotin).

This antibody recognises adiponectin, also known as ACRP30, apM-1, ADIPOQ. Adiponectin is a fat-derived hormone which suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, and acts as a messenger to allow communication between adipose tissue and other organs. Adiponectin can elicit several downstream signaling events, including the insulin signaling pathway. Anti-diabetic, anti-inflammatory, and anti-atherogenic effects of adiponectin have been identified, and the protein sensitizes cells to insulin. Decreased adiponecin levels may play a role in development of type 2 diabetes, and therefore, adiponectin has been suggested as a potential therapeutic target for diabetes. The biotinylated Mouse anti Human adiponectin antibody, clone D02-7B10 (MCA6175B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human adiponectin antibody, clone D05-9C7 (MCA6174GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human adiponectin (Glu19-Asn244).

Mouse

Monoclonal

D02-7B10

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human adiponectin antibody, cloneD02-7B10, recognizes adiponectin, also known as ACRP30, apM-1, ADIPOQ. Adiponectin is a fat-derived hormone which suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, and acts as a messenger to allow communication between adipose tissue and other organs (Wang and Scherer, 2016). Adiponectin can elicit several downstream signaling events, including the insulin signaling pathway. Anti-diabetic, anti-inflammatory, and anti-atherogenic effects of adiponectin have been identified, and the protein sensitizes cells to insulin. Decreased adiponecin levels may play a role in development of type 2 diabetes, and therefore, adiponectin has been suggested as a potential therapeutic target for diabetes (Achari and Jain 2017). The biotinylated Mouse anti Human adiponectin antibody, clone D02-7B10 (MCA6175B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human adiponectin antibody, clone D05-9C7 (MCA6174GA) as the capture antibody.

30 kDa adipocyte complement-related protein, ACDC, ACRP30, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, ADIPOQ, Adipose most abundant gene transcript 1 protein, apM-1, APM1, GBP28, Gelatin-binding protein

This product is for research use only. It is not intended for diagnostic or therapeutic use.