Recombinant Anti-Filaggrin Antibody [rFLG/1945] (A277886)

Anti-Filaggrin Antibody [rFLG/1945]

Recombinant mouse monoclonal [rFLG/1945] antibody to Filaggrin.

Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 198-288, of human Filaggrin. The exact sequence is proprietary.

Mouse

Monoclonal

rFLG/1945

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

26-45 kDa (Processed) / 350 kDa (Profilaggrin)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Filaggrin Antibody [rFLG/1945] - BSA and Azide free (A278474).

ATOD2, Epidermal filaggrin, Filaggrin precursor, FILA_HUMAN, Fillagrin, FLG, Profilaggrin