This antibody recognises human FGF 10 (fibroblast growth factor 10), a member of the heparin-binding growth factors family which act as promoters of cellular differentiation and proliferation, and therefore play key roles in embryonic development, morphogenesis, tissue regeneration and tumour growth and invasion.FGF 10 signals through binding to the FGF Receptor (FGFR) 2b, and has structural and biological activities similar to that of FGF 7. Defects in FGF 10 are responsible for the autosomal dominant disorders known as lacrimo-auriculo-dento-digital syndrome (LADDS), and aplasia of lacrimal and salivary glands (ALSG).
Applications
WB, IHC-P, ELISA
Dilutions
ELISA: 0.5 - 2 µg/ml, WB: 0.1 - 0.2 µg/ml
Reactivity
Human
Immunogen
Recombinant human FGF 10.
Host
Goat
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
1 mg/ml after reconstitution.
Product Form
Lyophilized
Reconstitution
Reconstitute with 0.1 ml of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
Formulation
Supplied in Phosphate Buffered Saline.
Storage
Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Goat anti Human FGF 10 antibody recognizes human FGF 10 (fibroblast growth factor 10), a member of the heparin-binding growth factors family which act as promoters of cellular differentiation and proliferation, and therefore play key roles in embryonic development, morphogenesis, tissue regeneration and tumour growth and invasion.FGF 10 signals through binding to the FGF Receptor (FGFR) 2b, and has structural and biological activities similar to that of FGF 7. Defects in FGF 10 are responsible for the autosomal dominant disorders known as lacrimo-auriculo-dento-digital syndrome (LADDS), and aplasia of lacrimal and salivary glands (ALSG).
Synonyms
BB213776, fd11d03, FGF 10, FGF-10, FGF10_HUMAN, Fibroblast growth factor 10, Keratinocyte growth factor 2, KGF 2, Produced by fibroblasts of urinary bladder lamina propria, wu:fd11d03, zgc:109774
