Recombinant Anti-Ferritin Heavy Chain Antibody [FTH/8700R] (A314953)

Anti-Ferritin Heavy Chain Antibody [FTH/8700R]

Recombinant rabbit monoclonal [FTH/8700R] antibody to Ferritin Heavy Chain.

Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.

Human liver tissue. Liver tissue lysate.

IHC: 1-2 µg/ml

Human

Recombinant human FTH1 protein fragment (around Amino Acids 58-180). The exact sequence is proprietary.

Rabbit

Monoclonal

FTH/8700R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

21 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Apoferritin, Cell proliferation inducing gene 15 protein, Cell proliferation-inducing gene 15 protein, F HC, Ferritin H subunit, Ferritin heavy polypeptide 1, FHC, FRIH, FRIH_HUMAN, FTH, FTH 1, FTH1, FTH1 protein, FTHL 6, FTHL6, Iron overload autosomal dominant, MGC104426, N-terminally processed, OK/SW-cl.84, PIG 15, PIG15, Placenta immunoregulatory factor, PLIF, Proliferation inducing gene 15 protein, Proliferation inducing protein 15