Anti-Factor H Antibody [C01-4A10] (Biotin) (A279928)

Anti-Factor H Antibody [C01-4A10] (Biotin)

Mouse monoclonal [C01-4A10] antibody to Factor H (Biotin).

This antibody recognises complement factor H, also known as H Factor1. Complement factor H is a major regulatory protein of the alternative activation pathway of the complement cascade. It regulates this pathway by targeting C3 convertase (C3bBb) for degradation and by acting as a co-factor in the cleavage and inactivation of C3b. Complement factor H is a soluble ~155 kDa glycoprotein present in serum at a relatively high concentration, averaging between 200 – 800 ug/ml. It is also expressed locally by many cells types including epithelial cells and platelets (Ferreira et al. 2010, Parente et al. 2017).Due to the major regulatory functionality of complement factor H, mutations and polymorphisms of the encoding gene are associated with inappropriate recognition of “self” cell markers in patients and consequently results in complement mediated tissue damage and disease. These mutations are associated with various diseases including atypical haemolytic uremic syndrome and C3 glomerulophathy (Martinez-Barricate et al. 2008, Cserhalmi et al. 2017).The biotinylated Mouse anti Human complement factor H antibody, clone C01-4A10 (MCA6229B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human complement factor H antibody, clone C06-2F3 (MCA6228GA) as the capture antibody.

ELISA: 1 µg/ml

Human

Purified native human complement factor H.

Mouse

Monoclonal

C01-4A10

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human complement Factor H antibody, clone C01-4A10, recognizes, complement factor H, also known as H Factor1. Complement factor H is a major regulatory protein of the alternative activation pathway of the complement cascade. It regulates this pathway by targeting C3 convertase (C3bBb) for degradation and by acting as a co-factor in the cleavage and inactivation of C3b. Complement factor H is a soluble ~155 kDa glycoprotein present in serum at a relatively high concentration, averaging between 200 – 800 ug/ml. It is also expressed locally by many cells types including epithelial cells and platelets (Ferreira et al. 2010, Parente et al. 2017). Due to the major regulatory functionality of complement factor H, mutations and polymorphisms of the encoding gene are associated with inappropriate recognition of “self” cell markers in patients and consequently results in complement mediated tissue damage and disease. These mutations are associated with various diseases including atypical haemolytic uremic syndrome and C3 glomerulophathy (Martinez-Barricate et al. 2008, Cserhalmi et al. 2017).The biotinylated Mouse anti Human complement factor H antibody, clone C01-4A10 (MCA6229B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human complement factor H antibody, clone C06-2F3 (MCA6228GA) as the capture antibody.

adrenomedullin binding protein, age related maculopathy susceptibility 1, AHUS 1, AHUS1, AMBP 1, AMBP1, ARMD 4, ARMD4, ARMS 1, ARMS1, beta 1 H globulin, beta 1H, beta1H, CFAH_HUMAN, CFH, CFHL 3, CFHL3, Complement factor H, complement factor H, isoform b, factor H like 1, FH, FHL 1, FHL1, H factor 1, H factor 1 (complement), H factor 2 (complement), HF, HF 1, HF 2, HF1, HF2, HUS, MGC88246

This product is for research use only. It is not intended for diagnostic or therapeutic use.