Recombinant Anti-Estrogen Receptor alpha Antibody [ESR1/6983R] (A277978)

Anti-Estrogen Receptor alpha Antibody [ESR1/6983R]

Recombinant rabbit monoclonal [ESR1/6983R] antibody to Estrogen Receptor alpha.

Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems.Studies have shown ER α is present in the nuclei of epithelial cells in normal breast and endometrial tissues, as well as a subset of breast carcinomas.Studies with immunohistochemical assay show that positive steroid hormone status has predicted favorable overall, survival, independently of hormonal treatment. Secondly, ER α can be used as a tumor marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 495-595, of human Estrogen Receptor alpha. The exact sequence is proprietary.

Rabbit

Monoclonal

ESR1/6983R

IgG

kappa

Protein A/G chromatography.

200 µg/ml

~67 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Estrogen Receptor alpha Antibody [ESR1/6983R] - BSA and Azide free (A278566).

DKFZp686N23123, ER, ER alpha, ER-alpha, Era, ESR, ESR1, ESR1_HUMAN, ESRA, Estradiol receptor, Estrogen nuclear receptor alpha, Estrogen receptor, Estrogen receptor 1, Estrogen receptor alpha 3*,4,5,6,7*/822 isoform, Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform, Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform, Estrogen receptor alpha delta 4 +49 isoform, Estrogen receptor alpha delta 4*,5,6,7*/654 isoform, Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform, Estrogen receptor alpha E1 E2 1 2, Estrogen receptor alpha E1 N2 E2 1 2, ESTRR, NR3A1, Nuclear receptor subfamily 3 group A member 1