Recombinant Anti-E2F4 Antibody [E2F4/8645R] (A314902)

$765

Recombinant rabbit monoclonal [E2F4/8645R] antibody to E2F4 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-E2F4 Antibody [E2F4/8645R]
Description
Recombinant rabbit monoclonal [E2F4/8645R] antibody to E2F4.
Specificity
The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcription regulators including E2F-2, E2F-3, E2F-4, E2F-5, E2F-6 and E2F-7 each of which forms heterodimers with a second protein, DP-1, forming an active E2F transcriptional regulatory complex.
Applications
IHC-P
Positive Control
Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 1-100) of human E2F4 protein. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
E2F4/8645R
Isotype
IgG
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
60 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
E2F 4, E2F transcription factor 4, E2F transcription factor 4 p107/p130 binding, E2F-4, E2F4_HUMAN, p107/p130 binding protein, Transcription factor E2F 4, Transcription factor E2F4
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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