This antibody recognises human DRAM, a lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. DRAM is significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.
Applications
WB, IHC-P
Dilutions
IHC-P 1: 2.5 µg/ml, WB: 0.5 - 1 µg/ml
Reactivity
Human, Mouse, Rat
Immunogen
A peptide corresponding to 16 amino acids near the C-terminus of human DRAM.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
1 mg/ml
Molecular Weight
Approximately 16 and 31 kDa in 293 cell lysate
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti DRAM (C-terminal) antibody recognizes human DRAM, a lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. DRAM is significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.
Synonyms
Damage regulated autophagy modulator, Damage-regulated autophagy modulator, Damage-regulated autophagy modulator 1, DNA damage-regulated autophagy modulator protein 1, dram1, DRAM1_HUMAN, FLJ11259
