Anti-DNMT3A Antibody [PCRP-DNMT3A-1E2] - BSA and Azide free (A251529)

Mouse monoclonal [PCRP-DNMT3A-1E2] antibody to DNMT3A for WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-DNMT3A Antibody [PCRP-DNMT3A-1E2] - BSA and Azide free
Description
Mouse monoclonal [PCRP-DNMT3A-1E2] antibody to DNMT3A.
Specificity
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000 full-length human proteins. DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Sadenosyl-L-methionin
Applications
WB, IHC-P
Dilutions
WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human DNMT3A protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-DNMT3A-1E2
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
102 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-DNMT3A Antibody [PCRP-DNMT3A-1E2] (A248347).
Synonyms
DNA (cytosine 5) methyltransferase 3 alpha, DNA (cytosine 5) methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3 alpha, DNA methyltransferase 3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, DNM3A_HUMAN, DNMT, DNMT 3a, DNMT3A2, M.HsaIIIA, MCMT, OTTHUMP00000201149, TBRS
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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