Anti-Desmoglein 1 Antibody [32-2B] - BSA and Azide free
Description
Mouse monoclonal [32-2B] antibody to Desmoglein 1.
Specificity
This antibody recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis.
Host
Mouse
Clonality
Monoclonal
Clone ID
32-2B
Isotype
IgG2a
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
150 kDa (precursor) / 160 kDa (mature)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
SDS-PAGE analysis of Anti-Desmoglein 1 Antibody [32-2B] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Publishing research using Anti-Desmoglein 1 Antibody [32-2B] - BSA and Azide free (A251551)? Please let us know so that we can list the citation on this page.
Alternative products to Anti-Desmoglein 1 Antibody [32-2B] - BSA and Azide free (A251551)