Anti-Desmin Antibody [DES/4526] (A314885)

Anti-Desmin Antibody [DES/4526]

Mouse monoclonal [DES/4526] antibody to Desmin.

Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

SJRH30 cells. Human uterus, small intestine or leiomyosarcoma.

IHC: 1-2 µg/ml

Human

Recombinant full-length human desmin protein.

Mouse

Monoclonal

DES/4526

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

52 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CMD1I, CSM1, CSM2, DES, DESM_HUMAN, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate filament protein, OTTHUMP00000064865