Recombinant chimeric monoclonal antibody to Claudin18.
Anwendungen
ELISA, FACS, Functional Assay, In Vivo
Reaktivität
Human, Mouse
Wirt
Chimeric
Klonalität
Monoclonal
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat
Unconjugated
Reinigung
Protein A affinity chromatography.
Konzentration
Reconstitution dependent.
Molekulargewicht
This antibody has a predicted MW of 150 kDa.
Reinheit
> 95% (by SDS-PAGE and SEC-HPLC).
Produktform
Lyophilized
Rekonstitution
Reconstitute with 100µl of sterile double-distilled water to bring antibody to 1mg/ml concentration. Gently shake to solubilize completely. Do not vortex!
Formulierung
Lyophilized from 25mM Histadine, pH 6.2, with 8% Sucrose and 0.01% Tween80.
Lagerung
Shipped at 4°C. Lyophilized: Store at -20°C to -80°C. Reconstituted: Aliquot and store at -80°C. Product is stable for one year. Avoid freeze/thaw cycles.
SDS-PAGE analysis of Zolbetuximab Biosimilar - Anti-Claudin18 Antibody - Low endotoxin, Azide free (A323855) under reducing (R) conditions confirms that the purity of this antibody is greater than 95%.
SEC-HPLC analysis of Zolbetuximab Biosimilar - Anti-Claudin18 Antibody - Low endotoxin, Azide free (A323855) confirms that the purity of this antibody is 96.05%.
Zolbetuximab Biosimilar - Anti-Claudin18 Antibody - Low endotoxin, Azide free (A323855) inhibited the tumor growth of CLDN18.2-MC38 (Mouse colorectal cancer cells) on C57BL/6N mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 42.3% at 10 mpk at D25.
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