Anti-WTAP Antikörper [PCRP-WTAP-1A4] (A315795)

Anti-WTAP Antibody [PCRP-WTAP-1A4]

Mouse monoclonal [PCRP-WTAP-1A4] antibody to WTAP.

Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3 UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.

Flow Cytometry, IHC-P

Ubiquitous expression.

Flow Cytometry: 1-2 µg/million cells, IHC: 1-2 µg/ml

Human

Recombinant full-length human WTAP protein.

Mouse

Monoclonal

PCRP-WTAP-1A4

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

44.2 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DKFZp686F20131, Female-lethal(2)D homolog, FL2D_HUMAN, hFL(2)D, KIAA0105, MGC3925, Mum2, OTTHUMP00000017522, OTTHUMP00000017523, PNAS 132, PNAS-132, PNAS132, Pre mRNA splicing regulator WTAP, Pre-mRNA-splicing regulator WTAP, Putative pre mRNA splicing regulator female lethal 2D homolog, Putative pre mRNA splicing regulator female lethal(2D), Putative pre-mRNA splicing regulator female lethal(2D) homolog, putative pre-mRNA splicing regulator female-lethal(2D), Wilms tumor 1 associated protein, Wilms tumor 1 associating protein, Wilms tumor 1-associating protein, Wilms' tumor 1 associating protein, Wilms' tumour 1-associating protein, WT1 associated protein, WT1-associated protein, WT1-associating protein