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Anti-WTAP Antikörper [PCRP-WTAP-1A4] (A315795)

$765

Monoklonal [PCRP-WTAP-1A4] Maus Antikörper gegen WTAP für Flow Cytometry und IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-WTAP Antibody [PCRP-WTAP-1A4]
Beschreibung
Mouse monoclonal [PCRP-WTAP-1A4] antibody to WTAP.
Spezifität
Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3 UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
Anwendungen
Flow Cytometry, IHC-P
Positivkontrolle
Ubiquitous expression.
Verdünnungen
Flow Cytometry: 1-2 µg/million cells, IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant full-length human WTAP protein.
Wirt
Mouse
Klonalität
Monoclonal
Klon
PCRP-WTAP-1A4
Isotyp
IgG2b
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
44.2 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
DKFZp686F20131, Female-lethal(2)D homolog, FL2D_HUMAN, hFL(2)D, KIAA0105, MGC3925, Mum2, OTTHUMP00000017522, OTTHUMP00000017523, PNAS 132, PNAS-132, PNAS132, Pre mRNA splicing regulator WTAP, Pre-mRNA-splicing regulator WTAP, Putative pre mRNA splicing regulator female lethal 2D homolog, Putative pre mRNA splicing regulator female lethal(2D), Putative pre-mRNA splicing regulator female lethal(2D) homolog, putative pre-mRNA splicing regulator female-lethal(2D), Wilms tumor 1 associated protein, Wilms tumor 1 associating protein, Wilms tumor 1-associating protein, Wilms' tumor 1 associating protein, Wilms' tumour 1-associating protein, WT1 associated protein, WT1-associated protein, WT1-associating protein
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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