Anti-TRAF1 Antikörper [TRAF1/3298] (A250213)

Name: Anti-TRAF1 Antibody [TRAF1/3298]
Brand: Antibodies.com
SKU: A250213
Price: 525.0 USD
Availability: InStock

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$525

Monoklonal [TRAF1/3298] Maus Antikörper gegen TRAF1 für IHC-P.

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Versand

Versandkosten

$40

Vorlaufzeit

Lieferung in 4-6 Werktagen

Kontakt

Telefon

+1 (314) 370-6046

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Stichworte:

Monospezifischer Antikörper

Produktdetails

Produktname

Anti-TRAF1 Antibody [TRAF1/3298]

Beschreibung

Mouse monoclonal [TRAF1/3298] antibody to TRAF1.

Spezifität

This antibody recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.

Anwendungen

IHC-P

Verdünnungen

IHC-P: 1-2 µg/ml

Reaktivität

Human

Immunogen

Recombinant fragment, around amino acids 73-219, of human TRAF1 protein. The exact sequence is proprietary.

Wirt

Mouse

Klonalität

Monoclonal

Klon

TRAF1/3298

Isotyp

IgG2b

Leichte Ketten

kappa

Konjugat

Unconjugated

Reinigung

Protein A/G chromatography.

Konzentration

200 µg/ml

Molekulargewicht

52 kDa

Produktform

Liquid

Formulierung

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Lagerung

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Allgemeine Hinweise

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TRAF1 Antibody [TRAF1/3298] - BSA and Azide free (A253393).

Synonyme

4732496E14Rik, EBI6, EBV induced protein 6, Epstein-Barr virus-induced protein 6, MGC:10353, Tnf receptor associated factor 1, TNF receptor-associated factor 1, TRAF 1, TRAF1_HUMAN

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Produktbilder (2)

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Figure 1: Immunohistochemistry - Anti-TRAF1 Antibody [TRAF1/3298] (A250213)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human spleen using Anti-TRAF1 Antibody [TRAF1/3298].

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Figure 2: Anti-TRAF1 Antibody [TRAF1/3298] (A250213)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-TRAF1 Antibody [TRAF1/3298]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.