This antibody recognises mouse TLR3, otherwise known as CD283 or Toll-like receptor 3. CD283 is a 905 amino acid ~105 kDa single pass type 1 transmembrane glycoprotein associated with endosomal membranes and member of the Toll-like receptor (TLR) family. CD283 functions as a receptor for double-stranded RNA (UniProt: Q99MB1).TLRs are expressed on the cell surface and the endocytic compartment and recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents. TLRs also initiate cell signaling to induce production of cytokines necessary for the innate immunity and subsequent adaptive immunity.

Anwendungen

IF, Flow Cytometry

Verdünnungen

Flow Cytometry: 1:25 - 1:200, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl.

Reaktivität

Mouse

Immunogen

Purified murine TLR3 extracellular domain protein.

Wirt

Rat

Klonalität

Monoclonal

Klon

11F8

Isotyp

IgG2a

Konjugat

Unconjugated

Reinigung

Protein G affinity chromatography of tissue culture supernatant.

Konzentration

1 mg/ml

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Lagerung

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Allgemeine Hinweise

Rat anti Mouse CD283 antibody, clone 11F8 recognizes mouse TLR3, otherwise known as CD283 or Toll-like receptor 3. CD283 is a 905 amino acid ~105 kDa single pass type 1 transmembrane glycoprotein associated with endosomal membranes and member of the Toll-like receptor (TLR) family. CD283 functions as a receptor for double-stranded RNA (UniProt: Q99MB1).TLRs are expressed on the cell surface and the endocytic compartment and recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents. TLRs also initiate cell signaling to induce production of cytokines necessary for the innate immunity and subsequent adaptive immunity.

Synonyme

CD283, CD283 antigen, IIAE2, TLR 3, TLR3/CD283, TLR3_HUMAN, Toll Like Receptor 3, Toll-like receptor 3

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.