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Anti-Thymidine Phosphorylase Antikörper [SPM322] (A248383)

Monoklonal [SPM322] Maus Antikörper gegen Thymidine Phosphorylase für WB, IP und IHC-P.

Alternative Formats and ConjugatesAlternative Formats

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Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
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Email
orders@antibodies.com
Produktname
Anti-Thymidine Phosphorylase Antibody [SPM322]
Beschreibung
Mouse monoclonal [SPM322] antibody to Thymidine Phosphorylase.
Spezifität
This antibody recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
Anwendungen
WB, IP, IHC-P
Verdünnungen
WB: 1-2 µg/ml, IP: 0.5-1 µg / 500 µg protein lysate, IHC-P: 1-2 µg/ml
Reaktivität
Human, Mouse, Rat
Immunogen
Recombinant full-length human Thymidine Phosphorylase protein.
Wirt
Mouse
Klonalität
Monoclonal
Klon
SPM322
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
55 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Thymidine Phosphorylase Antibody [SPM322] - BSA and Azide free (A251565).
Synonyme
ECGF, ECGF 1, ECGF1, Endothelial cell growth factor 1, Endothelial cell growth factor 1 platelet derived, Endothelial cell growth factor, platelet-derived, Gliostatin, hPD ECGF, MEDPS1, MNGIE, MTDPS1, PD ECGF, PD-ECGF, PDECGF, PDEGF, Platelet derived endothelial cell growth factor, Platelet derived endothelial growth factor, Platelet-derived endothelial cell growth factor, TdRPase, TP, Tymp, TYPH_HUMAN
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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