This antibody recognises Transducin Beta Like 1 X-Linked (TBL1X), also known as SMAP55 and F-box-like/WD repeat-containing protein TBL1X. TBL1X is linked to the X chromosome, while TBL1Y is encoded by the same gene on the Y chromosome, and both are closely related to the co-repressor of nuclear hormone transcription factors TBLR1. Similarly, TBL1X is an F-box-like protein that plays an essential role in the silencing mediator for retinoid and thyroid hormone receptors complex. TBLR1 functions as an oncogene and is upregulated in colorectal cancer, and TBLR1 knockdown has been shown to inhibit invasive growth of head and neck squamous cell carcinoma cells (Li and Wang. 2008).

Anwendungen

Verdünnungen

WB: 1:500 - 1:2,000

Reaktivität

Human

Immunogen

Synthetic peptide corresponding to amino acids 100-200 of human TBL1X (NP_005638.1).

Sequenz

LISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEEN

Wirt

Rabbit

Klonalität

Polyclonal

Isotyp

IgG

Konjugat

Unconjugated

Konzentration

Lot Specific

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Lagerung

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Allgemeine Hinweise

Rabbit anti TBL1X antibody recognizes Transducin Beta Like 1 X-Linked (TBL1X), also known as SMAP55 and F-box-like/WD repeat-containing protein TBL1X. TBL1X is linked to the X chromosome, while TBL1Y is encoded by the same gene on the Y chromosome, and both are closely related to the co-repressor of nuclear hormone transcription factors TBLR1 (Zhang et al. 2006). Similarly, TBL1X is an F-box-like protein that plays an essential role in the silencing mediator for retinoid and thyroid hormone receptors complex (Heinen et al. 2016). TBLR1 functions as an oncogene and is upregulated in colorectal cancer, and TBLR1 knockdown has been shown to inhibit invasive growth of head and neck squamous cell carcinoma cells (Li and Wang. 2008).

Synonyme

EBI, F box like/WD repeat protein TBL1X, F-box-like/WD repeat-containing protein TBL1X, SMAP 55, SMAP55, TBL 1, TBL 1X, TBL1, TBL1X_HUMAN, Transducin (beta) like 1, Transducin (beta) like 1 X linked, Transducin (beta) like 1X linked, Transducin beta like 1 X linked, Transducin beta like 1X, Transducin beta like 1X protein, Transducin beta like protein 1, X linked, Transducin beta-like protein 1X, Transducin-beta-like protein 1, X-linked

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.