Anti-STAT5B Antikörper [STAT5B/2611] (A250065)

Anti-STAT5B Antibody [STAT5B/2611]

Mouse monoclonal [STAT5B/2611] antibody to STAT5B.

Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human STAT5B protein.

Mouse

Monoclonal

STAT5B/2611

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

94 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-STAT5B Antibody [STAT5B/2611] - BSA and Azide free (A253245).

Signal transducer and activator of transcription 5B, STA5B_HUMAN, STAT5, Transcription factor STAT5B