General Notes
Mouse anti Dog serum amyloid A, clone VSA34, specifically recognizes the canine serum amyloid A (SAA) protein, an acute phase protein belonging to the SAA family. SAA is secreted into the plasma by the liver following injury or infection.SAA is a widely used marker of inflamation as elevated levels of SAA may be detected in the blood of the animal following infection or tissue trauma.Serum amyloid A is highly conserved between species with canine SAA being similar in structure to SAA in other species. Mouse anti Dog serum amyloid A, clone VSA34 recognizes both equine and feline SAA. Structurally canine, feline and equine SAA differ from human SAA in that they contain an 8 aa insert in the central region of the sequence, human SSA being 104 aa, equine SAA 110 aa while canine and feline have 111 aa.Mouse anti Dog serum amyloid A, clone VSA34 is raised against dog, but may be used to detect SAA in cats and horses. Clone VSA34 may be use as a detection reagent along with clone SAA19 (MCA6030GA) as the capture reagent in the development of immunoassays to detect SAA in dogs, cats and horses along with recombinant SAA (for canine, product code PDP006, for feline, product code PFP003 and equine, product code PEP006) as a standard.