Anti-RBP4 Antikörper [RBP4/4045] (A249851)

Name: Anti-RBP4 Antibody [RBP4/4045]
Brand: Antibodies.com
SKU: A249851
Price: 525.0 USD
Availability: InStock

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$525

Monoklonal [RBP4/4045] Maus Antikörper gegen RBP4 für IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Versand

Versandkosten

$40

Vorlaufzeit

Lieferung in 4-6 Werktagen

Kontakt

Telefon

+1 (314) 370-6046

orders@antibodies.com

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Stichworte:

Monospezifischer Antikörper

Produktdetails

Produktname

Anti-RBP4 Antibody [RBP4/4045]

Beschreibung

Mouse monoclonal [RBP4/4045] antibody to RBP4.

Spezifität

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

Anwendungen

IHC-P

Verdünnungen

IHC-P: 1-2 µg/ml

Reaktivität

Human

Immunogen

Recombinant fragment, around amino acids 29-148, of human RBP4 protein. The exact sequence is proprietary.

Wirt

Mouse

Klonalität

Monoclonal

Klon

RBP4/4045

Isotyp

IgG2c

Leichte Ketten

kappa

Konjugat

Unconjugated

Reinigung

Protein A/G chromatography.

Konzentration

200 µg/ml

Molekulargewicht

25 kDa

Produktform

Liquid

Formulierung

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Lagerung

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Allgemeine Hinweise

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-RBP4 Antibody [RBP4/4045] - BSA and Azide free (A253031).

Synonyme

OTTHUMP00000020114, OTTHUMP00000020115, OTTHUMP00000020116, Plasma retinol binding protein 4, Plasma retinol-binding protein, Plasma retinol-binding protein(1-176), PRBP, PRO2222, RBP, RDCCAS, RET4_HUMAN, Retinol binding protein 4, Retinol binding protein 4 interstitial, Retinol binding protein 4 plasma

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Produktbilder (3)

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Figure 1: Immunohistochemistry - Anti-RBP4 Antibody [RBP4/4045] (A249851)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney using Anti-RBP4 Antibody [RBP4/4045].

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Figure 2: Immunohistochemistry - Anti-RBP4 Antibody [RBP4/4045] (A249851)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney using Anti-RBP4 Antibody [RBP4/4045].

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Figure 3: Anti-RBP4 Antibody [RBP4/4045] (A249851)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-RBP4 Antibody [RBP4/4045]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.