Rekombinant Anti-Progesterone Receptor Antikörper [PGR/6854R] (A278044)

Anti-Progesterone Receptor Antibody [PGR/6854R]

Recombinant rabbit monoclonal [PGR/6854R] antibody to Progesterone Receptor.

Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans' islets. The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 400-600, of human Progesterone Receptor. The exact sequence is proprietary.

Rabbit

Monoclonal

PGR/6854R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

PR-A (81 kDa) / PR-B (116 kDa)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Progesterone Receptor Antibody [PGR/6854R] - BSA and Azide free (A278632).

NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, PRGR_HUMAN, Progestin receptor form A, Progestin receptor form B