TNFSF9 ist ein Gen, das durch das Symbol TNFSF9 kodiert wird. Es ist auch bekannt als: Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL. TNFSF9 hat eine Masse von 26.63kDa und eine Aminosäurelänge von 254.
Wir bieten 4 TNFSF9proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Entrez Zusammenfassung
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Gewebespezifität
Expressed in brain, placenta, lung, skeletal muscle and kidney.
Sequenzähnlichkeiten
Belongs to the tumor necrosis factor family.
