TARC ist ein Gen, das durch das Symbol CCL17 kodiert wird. Es ist auch bekannt als: C-C motif chemokine 17; CC chemokine Small-inducible cytokine A17; Thymus and activation-regulated chemokine; CCL17; SCYA17. TARC hat eine Masse von 10.51kDa und eine Aminosäurelänge von 94.
Wir bieten 3 TARCproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Entrez Zusammenfassung
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
Gewebespezifität
Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.
Sequenzähnlichkeiten
Belongs to the intercrine beta (chemokine CC) family.
