Serum Amyloid A ist ein Gen, das durch das Symbol SAA1 kodiert wird. Es ist auch bekannt als: Serum amyloid A-1 protein; SAA; SAA1. Serum Amyloid A hat eine Masse von 13.53kDa und eine Aminosäurelänge von 122.
Wir bieten 7 Serum Amyloid Aproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Major acute phase protein.
Entrez Zusammenfassung
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
Gewebespezifität
Expressed by the liver; secreted in plasma (at protein level).
Sequenzähnlichkeiten
Belongs to the SAA family.
Posttranslationale Modifikation
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
