PPM1A ist ein Gen, das durch das Symbol PPM1A kodiert wird. Im Allgemeinen auch bezeichnet als: Protein phosphatase 1A; Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IA; PPPM1A. PPM1A hat eine Masse von 42.45kDa und eine Aminosäurelänge von 382.
Wir bieten 1 PPM1Aproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Sequenzähnlichkeiten
Belongs to the PP2C family.
Posttranslationale Modifikation
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
Zellort
Nucleus. Cytoplasm > Cytosol. Membrane.
Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
