Persephin ist ein Gen, das durch das Symbol PSPN kodiert wird. Im Allgemeinen auch bezeichnet als: PSP; PSPN. Persephin hat eine Masse von 16.6kDa und eine Aminosäurelänge von 156.
Wir bieten 2 Persephinproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
Entrez Zusammenfassung
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma.
Sequenzähnlichkeiten
Belongs to the TGF-beta family. GDNF subfamily.
