Periostin ist ein Gen, das durch das Symbol POSTN kodiert wird. Im Allgemeinen auch bezeichnet als: PN; Osteoblast-specific factor 2; OSF-2; POSTN; OSF2. Periostin hat eine Masse von 93.31kDa und eine Aminosäurelänge von 836.
Wir bieten 3 Periostinproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
Entrez Zusammenfassung
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gewebespezifität
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
Posttranslationale Modifikation
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).
Zellort
Golgi apparatus. Secreted. Secreted > Extracellular space > Extracellular matrix.
Colocalizes with BMP1 in the Golgi.
