Osteopontin ist ein Gen, das durch das Symbol SPP1 kodiert wird. Im Allgemeinen auch bezeichnet als: Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin; SPP1; BNSP; OPN. Osteopontin hat eine Masse von 35.42kDa und eine Aminosäurelänge von 314.
Wir bieten 5 Osteopontinproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Entrez Zusammenfassung
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Bone. Found in plasma.
Sequenzähnlichkeiten
Belongs to the osteopontin family.
Posttranslationale Modifikation
Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.
