Interferon gamma ist ein Gen, das durch das Symbol IFNG kodiert wird. Im Allgemeinen auch bezeichnet als: IFN-gamma; Immune interferon; IFNG. Interferon gamma hat eine Masse von 19.35kDa, eine Aminosäurelänge von 166, und ist an Aplastic anemia beteiligt.
Wir bieten 13 Interferon gammaproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Entrez Zusammenfassung
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.
Gewebespezifität
Released primarily from activated T lymphocytes.
Rolle bei Krankheiten
Aplastic anemia: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.
Sequenzähnlichkeiten
Belongs to the type II (or gamma) interferon family.
Posttranslationale Modifikation
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
