IL13 ist ein Gen, das durch das Symbol IL13 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-13; IL-13; NC30. IL13 hat eine Masse von 15.82kDa, eine Aminosäurelänge von 146, und ist an Allergic rhinitis beteiligt.
Wir bieten 11 IL13proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).
Entrez Zusammenfassung
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Rolle bei Krankheiten
Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
Sequenzähnlichkeiten
Belongs to the IL-4/IL-13 family.
