IGFBP1 ist ein Gen, das durch das Symbol IGFBP1 kodiert wird. Im Allgemeinen auch bezeichnet als: Insulin-like growth factor-binding protein 1; IBP-1; Placental protein 12; PP12; IBP1. IGFBP1 hat eine Masse von 27.9kDa und eine Aminosäurelänge von 259.
Wir bieten 3 IGFBP1proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Entrez Zusammenfassung
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.
Posttranslationale Modifikation
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
