Iba1 ist ein Gen, das durch das Symbol AIF1 kodiert wird. Im Allgemeinen auch bezeichnet als: Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1; Protein G1; AIF1; G1. Iba1 hat eine Masse von 16.7kDa und eine Aminosäurelänge von 147.
Wir bieten 1 Iba1proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Entrez Zusammenfassung
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.
Gewebespezifität
Detected in T-lymphocytes and peripheral blood mononuclear cells.
Posttranslationale Modifikation
Phosphorylated on serine residues.
Zellort
Cytoplasm > Cytoskeleton. Cell projection > Ruffle membrane. Cell projection > Phagocytic cup.
Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
