Hexokinase II ist ein Gen, das durch das Symbol HK2 kodiert wird. Im Allgemeinen auch bezeichnet als: Hexokinase-2; Hexokinase type II; HK II; Hexokinase-B; Muscle form hexokinase; HK2. Hexokinase II hat eine Masse von 102.38kDa und eine Aminosäurelänge von 917.
Wir bieten 1 Hexokinase IIproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175).
Entrez Zusammenfassung
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
Gewebespezifität
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Sequenzähnlichkeiten
Belongs to the hexokinase family.
Zellort
Mitochondrion outer membrane. Cytoplasm > Cytosol.
The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175).
