Guanylate kinase ist ein Gen, das durch das Symbol GUK1 kodiert wird. Im Allgemeinen auch bezeichnet als: GMP kinase 1; GUK1; GMK; GMPK. Guanylate kinase hat eine Masse von 21.73kDa und eine Aminosäurelänge von 197.
Wir bieten 2 Guanylate kinaseproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664).
Entrez Zusammenfassung
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Widely expressed.
Sequenzähnlichkeiten
Belongs to the guanylate kinase family.
Zellort
Photoreceptor inner segment. Cytoplasm > Cytosol.
Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer.
