Granzyme B ist ein Gen, das durch das Symbol GZMB kodiert wird. Im Allgemeinen auch bezeichnet als: C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMB; CGL1; CSPB; CTLA1; GRB. Granzyme B hat eine Masse von 27.72kDa und eine Aminosäurelänge von 247.
Wir bieten 6 Granzyme Bproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Entrez Zusammenfassung
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.
Sequenzähnlichkeiten
Belongs to the peptidase S1 family. Granzyme subfamily.
Zellort
Cytoplasmic granule.
Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
