GLO1 ist ein Gen, das durch das Symbol GLO1 kodiert wird. Im Allgemeinen auch bezeichnet als: Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase. GLO1 hat eine Masse von 20.78kDa und eine Aminosäurelänge von 184.
Wir bieten 3 GLO1proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
Entrez Zusammenfassung
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.
Sequenzähnlichkeiten
Belongs to the glyoxalase I family.
Posttranslationale Modifikation
Glutathionylation at Cys-139 inhibits enzyme activity.
