Eotaxin ist ein Gen, das durch das Symbol CCL11 kodiert wird. Andere Namen sind: C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11; CCL11; SCYA11. Eotaxin hat eine Masse von 10.73kDa und eine Aminosäurelänge von 97.
Wir bieten 7 Eotaxinproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Entrez Zusammenfassung
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
Sequenzähnlichkeiten
Belongs to the intercrine beta (chemokine CC) family.
Posttranslationale Modifikation
O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.
