CXCL14 ist ein Gen, das durch das Symbol CXCL14 kodiert wird. Andere Namen sind: C-X-C motif chemokine 14; Chemokine BRAK; MIP-2G; Small-inducible cytokine B14; MIP2G; NJAC; SCYB14. CXCL14 hat eine Masse von 13.08kDa und eine Aminosäurelänge von 111.
Wir bieten 6 CXCL14proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
Entrez Zusammenfassung
This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
Gewebespezifität
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.
Sequenzähnlichkeiten
Belongs to the intercrine alpha (chemokine CxC) family.
Posttranslationale Modifikation
Ubiquitinated, followed by degradation by the proteasome.
