CNTF ist ein Gen, das durch das Symbol CNTF kodiert wird. Es ist auch bekannt als Ciliary neurotrophic factor. CNTF hat eine Masse von 22.93kDa und eine Aminosäurelänge von 200.
Wir bieten 8 CNTFproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Entrez Zusammenfassung
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Gewebespezifität
Nervous system.
Sequenzähnlichkeiten
Belongs to the CNTF family.
