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CD79b Proteine

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CD79b ist ein Gen, das durch das Symbol CD79B kodiert wird. Andere Namen sind: B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; B29; IGB. CD79b hat eine Masse von 26.05kDa, eine Aminosäurelänge von 229, und ist an Agammaglobulinemia 6, autosomal recessive beteiligt.

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Gen- und Proteininformationen

UniProt Zusammenfassung
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Entrez Zusammenfassung
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.
Gewebespezifität
B-cells.
Rolle bei Krankheiten
Agammaglobulinemia 6, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Posttranslationale Modifikation
Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
Zellort
Cell membrane.

Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
SDS-PAGE - Recombinant Human CD79b Protein (Fc Tag) (A317868) - Antibodies.com
(2)
SDS-PAGE - Recombinant Cynomolgus macaque CD79b Protein (Fc Tag) (A324907) - Antibodies.com
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