CD33 ist ein Gen, das durch das Symbol CD33 kodiert wird. Andere Namen sind: Myeloid cell surface antigen Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; SIGLEC3. CD33 hat eine Masse von 39.83kDa und eine Aminosäurelänge von 364.
Wir bieten 6 CD33proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).
Gewebespezifität
Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Posttranslationale Modifikation
Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition.
