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CD27 Proteine

6 Products

CD27 ist ein Gen, das durch das Symbol CD27 kodiert wird. Andere Namen sind: CD27 antigenL receptor; T-cell activation antigen T14; Tumor necrosis factor receptor superfamily member 7; TNFRSF7. CD27 hat eine Masse von 29.14kDa, eine Aminosäurelänge von 260, und ist an Lymphoproliferative syndrome 2 beteiligt.

Wir bieten 6 CD27proteine ​​an

Gen- und Proteininformationen

UniProt Zusammenfassung
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Gewebespezifität
Found in most T-lymphocytes.
Rolle bei Krankheiten
Lymphoproliferative syndrome 2: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Posttranslationale Modifikation
Phosphorylated.
Zellort
Membrane.
SDS-PAGE - Recombinant Human CD27 Protein (Fc Tag) (A318253) - Antibodies.com
(4)
SDS-PAGE - Recombinant Human CD27 Protein (Fc Chimera 6xHis Tag) (A318395) - Antibodies.com
(4)
SDS-PAGE - Recombinant Mouse CD27 Protein (Fc Tag) (A317529) - Antibodies.com
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