CD226 ist ein Gen, das durch das Symbol CD226 kodiert wird. Andere Namen sind: CD226 antigen; DNAX accessory molecule 1; DNAM-1; DNAM1. CD226 hat eine Masse von 38.61kDa und eine Aminosäurelänge von 336.
Wir bieten 4 CD226proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
Entrez Zusammenfassung
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Expressed by peripheral blood T-lymphocytes.
