CCR8 ist ein Gen, das durch das Symbol CCR8 kodiert wird. Andere Namen sind: C-C chemokine receptor type 8; C-C CKR-8; CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1; CKRL1; CMKBR8. CCR8 hat eine Masse von 40.84kDa und eine Aminosäurelänge von 355.
Wir bieten 6 CCR8proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Entrez Zusammenfassung
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
