c-Jun ist ein Gen, das durch das Symbol JUN kodiert wird. Andere Namen sind: Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene V-jun avian sarcoma virus 17 oncogene homolog; p39; JUN. c-Jun hat eine Masse von 35.68kDa und eine Aminosäurelänge von 331.
Wir bieten 2 c-Junproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Entrez Zusammenfassung
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Gewebespezifität
Expressed in the developing and adult prostate and prostate cancer cells.
Sequenzähnlichkeiten
Belongs to the bZIP family. Jun subfamily.
Posttranslationale Modifikation
Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).
