BNP ist ein Gen, das durch das Symbol NPPB kodiert wird. Andere Namen sind: Natriuretic peptides B; Gamma-brain natriuretic peptide; NPPB. BNP hat eine Masse von 14.73kDa und eine Aminosäurelänge von 134.
Wir bieten 6 BNPproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Entrez Zusammenfassung
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
Gewebespezifität
Brain and also in atria, but at much lower levels than ANP.
Sequenzähnlichkeiten
Belongs to the natriuretic peptide family.
Posttranslationale Modifikation
The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
