Betacellulin ist ein Gen, das durch das Symbol BTC kodiert wird. Es ist auch bekannt als ProBTC. Betacellulin hat eine Masse von 19.75kDa und eine Aminosäurelänge von 178.
Wir bieten 6 Betacellulinproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Entrez Zusammenfassung
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.
Gewebespezifität
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
Zellort
Secreted > Extracellular space.
