BCA1 ist ein Gen, das durch das Symbol CXCL13 kodiert wird. Andere Namen sind: C-X-C motif chemokine 13; Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13; CXCL13; BLC; SCYB13. BCA1 hat eine Masse von 12.66kDa und eine Aminosäurelänge von 109.
Wir bieten 4 BCA1proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Entrez Zusammenfassung
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
Gewebespezifität
Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
Sequenzähnlichkeiten
Belongs to the intercrine alpha (chemokine CxC) family.
