XPA ist ein Gen, das durch das Symbol XPA kodiert wird. Es ist auch bekannt als: DNA repair protein complementing XP-A cells; Xeroderma pigmentosum group A-complementing proteinC. XPA hat eine Masse von 31.37kDa, eine Aminosäurelänge von 273, und ist an Xeroderma pigmentosum complementation group A beteiligt.
Wir bieten 9 antikörper gegen XPA, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Entrez Zusammenfassung
This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer.
Gewebespezifität
Expressed in various cell lines and in skin fibroblasts.
Rolle bei Krankheiten
Xeroderma pigmentosum complementation group A: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-A patients show the most severe skin symptoms and progressive neurological disorders.
Sequenzähnlichkeiten
Belongs to the XPA family.
Posttranslationale Modifikation
ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage.
