Vitamin D Binding protein ist ein Gen, das durch das Symbol GC kodiert wird. Es ist auch bekannt als: Vitamin D-binding protein; DBP; Gc protein-derived macrophage activating factor; Gc-MAF; Gc-globulin; Group-specific component; Gc; Vitamin D-binding protein-macrophage activating factor; DBP-maf; GC. Vitamin D Binding protein hat eine Masse von 52.92kDa und eine Aminosäurelänge von 474.
Wir bieten 10 antikörper gegen Vitamin D Binding protein, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.
Sequenzähnlichkeiten
Belongs to the ALB/AFP/VDB family.
Posttranslationale Modifikation
Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.
